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The Ministry of Science, Innovation and Universities (Ministerio de Ciencia, Innovación y Universidades – MICIU) and the State Research Agency (Agencia Estatal de Investigación – AEI) have granted the prestigious “Severo Ochoa Excellence Centre” accreditation to the Institut Català d’Investigació Química (ICIQ) for the third time. This is the highest recognition for scientific institutions in Spain, alongside the “María de Maeztu Excellence Unit” accreditation. The execution of the strategic research plan will last for four years, while the “Severo Ochoa Excellence Centre” accreditation will be valid for a maximum of six years, starting from 1 April 2025.

This recognition was granted following a rigorous evaluation and competitive selection process, based on scientific criteria and in line with the highest international standards. It highlights the leadership in research and the development of transformative institutional programmes aimed at consolidating the centre’s capabilities and contributing to the leadership of research.

With this new accreditation, ICIQ renews its membership in the SOMMa Alliance (Severo Ochoa and María de Maeztu), a network that brings together the most outstanding research centres and units in the country, reinforcing its commitment to open, competitive, and international science. Of the 17 accreditations granted in this call across Spain, two are located in the city of Tarragona: ICIQ (Severo Ochoa) and IPHES (María de Maeztu), reinforcing the city’s role as an emerging hub of leading scientific research.

This project has received funding from the Spanish State Research Agency/Ministry of Science, Innovation and Universities through the “Severo Ochoa” Centres of Excellence Programme 2024 (CEX2024-001469-S, MICIU/AEI/10.13039/501100011033).

ICIQ SEVERO OCHOA PREDOCTORAL FELLOWSHIPS FOR RESEARCHERS  2025 

(ICIQ-FPI-SO 2025_2nd call)

The ICIQ Severo Ochoa Predoctoral Fellowships for Researchers Training are aimed at exceptional graduate students from all over the world. These PhD studentships will support your enrolment in a training and research program in the field of chemistry, ultimately leading to the completion of a PhD in Chemistry in partnership with the Universitat Rovira i Virgili (URV).The PhD will be ascribed to the CEX2024-001469-S project funded by the ‘Ministerio de Ciencia, Innovación y Universidades / Agencia Estatal de Investigación (MICIU/AEI)’ in the framework of the 2024 ‘Centros de Excelencia «Severo Ochoa» y Unidades «María de Maeztu»’ call for proposals.

The PhD trainees will have the opportunity to receive comprehensive training in order to successfully prepare for their professional career in academia or industry.

You can learn more about the Severo Ochoa Programme and the available positions here.

This objective is achieved by the following activities:

• The performance of each individual research project is aligned with one of the research lines of the ICIQ-Severo Ochoa Strategic Plan - Innovative Catalysis, Renewable Energy Vectors, and Molecular Medicine- in a creative and stimulating scientific environment.
• The Thesis project will be supervised by two ICIQ Group Leaders (supervisor and co-supervisor) to ensure that the PhD student benefits from a multidisciplinary project and dual mentorship.
• A complementary training programme in both technical and soft skills is provided. The educational framework is designed to ensure a successful career: scientific seminars, hands-on training in the use of state-of-the-art scientific instrumentation, IP management, entrepreneurship, research integrity, knowledge and technology transfer, grant applications, project management, communication skills and career development. ICIQ provides a personalized annual training program for PhD students called SHARP (Severo Ochoa PhD Training Program), which occurs over two weeks and focuses on their specific PhD year.
• Opportunities for short-term placements in distinguished international research institutions.

These fellowships are addressed to highly qualified, motivated and talented graduate students with a keen interest in research in Chemistry or adjacent areas. Candidates should have an excellent academic record, a strong commitment to scientific research and a solid working knowledge of English.

The process of evaluation and selection guarantees the principles of competition, publicity and transparency.

I. Available positions: See Annex

II. Application process

The entire application process will be completed online. Applicants must apply via ICIQ’s Career Portal. Applications sent by email or any other means will be ineligible.

Only one application per person will be considered. In case of multiple applications, only the first application submitted will be taken into consideration.

After completing the online form, applicants must attach the following documents:

1. A full Curriculum Vitae (maximum two (2) DIN A4 pages, in PDF format). It should include education, work or research experience, publications, conferences, grants and awards, other relevant merits and contact details for letters of recommendation.
   
2. A personal statement that describes the applicant’s academic background, research experience and career goals (maximum two (2) DIN A4 pages, in PDF format). Candidates must be able to communicate their interests and how these align with ICIQ and the Severo Ochoa Predoctoral Fellowships for Researchers Training. Candidates should also mention the research groups where they would like to carry out their PhD and the reasons why they are interested in a particular research project.
   
3. Official transcripts of BSc and MSc studies in PDF format. A scanned copy of the certified academic record of the studies granting access to the PhD programme (BSc and MSc). Candidates must have completed their Master’s degree by the time the fellowship starts to be eligible for the program (please refer to section III. Eligibility Criteria for further information on the eligibility requirements). For academic records not issued in Catalan, Spanish or English, a certified translation in English should be provided; otherwise, they will be ineligible and, therefore, not taken into consideration. For degrees obtained in foreign institutions, the academic record must include the range of marks used in the corresponding countries and the minimum mark to pass, as well as the hours or ECTS and marks for each subject.
   
4. Contact details for letters of recommendation of two University professors, researchers in industry or other relevant individuals who can assess the candidate’s potential for research. ICIQ will contact the people listed as references only if a candidate is shortlisted. We suggest informing your references.
   
5. English proficiency level. Applicants must provide evidence of their proficiency in written and oral communication in the English language, preferably, by the submission of a B2 certificate, Cambridge First Certificate, IELTS 6 or equivalent. This certificate is not mandatory but desirable; alternatively, late-stage candidates will be interviewed to assess their English level. Applicants from the Anglosphere (UK, Ireland, USA, Canada, Australia and New Zealand) are exempt from this requirement as native speakers.

NOTE: Although applicants can select up to two Thesis projects, the first option will be always prioritized for the selection process.

Once the application has been successfully completed, an acknowledgement e-mail will be automatically sent. Candidates must ensure that all information is included before the deadline. Incomplete applications will not be considered.

The application period opens on November 3, 2025 and closes at midnight (Spain time) on January 11, 2026.

III. Eligibility criteria

The fellowships are addressed to graduate students from any nationality who fulfil the following eligibility criteria:

1. Candidates must have a Master’s or an equivalent degree in the areas of Chemistry, Physics, Chemical Engineering, Pharmacy, or related disciplines, completed by October 2025, that allows them to be admitted in a Spanish PhD Program by the time the fellowship starts.
   
2. Individuals who already hold a PhD degree, whether from a Spanish or foreign university, or those who have previously benefited from a predoctoral training fellowship under the ‘Plan Estatal de Investigación, Desarrollo e Innovación Tecnológica’ or any of the previous Spanish National Plans by MICIU/AEI are not eligible.

When in doubt regarding the eligibility criteria, applicants should contact ICIQ’s Human Resources Unit at positions@iciq.es before submission of the application.

Candidates who fulfil the eligibility criteria will be evaluated according to the Evaluation Criteria described in section IV.

IV. Evaluation criteria

According to the 2024 ‘Centros de Excelencia «Severo Ochoa» y Unidades «María de Maeztu»’ call for proposals, the evaluation criteria are the following:

Criteria 1. Academic and/or scientific-technical career path of the candidate (up to 50 points).

Sub-criteria 1. a) Scientific-technical contributions (up to 45 points). The academic record and other curricular merits of the candidate will be assessed, as well as their suitability for the tasks to be carried out based on training and professional experience.

Sub-criteria 1. b) Mobility and internationalisation (up to 5 points). Short-term research stays in national and international institutions, universities, and industry will be assessed, considering the prestige of the entity hosting the stay and the activity carried out therein, as well as the impact of the research stays on the research career path of the candidate.

Criteria 2. Suitability of the candidate for the proposed research activities (up to 50 points). The candidate's suitability for the program, project, and planned research activities will be evaluated based on their prior training and experience. In this context, consideration will be given to the added value that undertaking the project would bring to their research career, as well as the value the candidate would contribute to the host institution and research groups.

V. Evaluation and Selection Process

The evaluation and selection of the candidates will be conducted by the ICIQ Severo Ochoa Committee for Predoctoral Training following the guidelines set by the 2024 ‘Centros de Excelencia «Severo Ochoa» y Unidades «María de Maeztu»’ call for proposals, supported by the Human Resources team, and following the procedure below:

1. The evaluation and selection process carried out under this call will observe the principles of the San Francisco Declaration on Research Assessment (DORA), signed in San Francisco, California, on December 16, 2012 (https://sfdora.org/read).
   
2. Submitted applications will be checked for eligibility, and those not fulfilling all the criteria will be rejected. It will not be possible to modify the application or to add missing documentation after the call deadline.
   
3. The selection will be based on the evaluation criteria described in Section IV. The threshold to be admitted to the program will be 65 points.
   
4. At the late stages of the selection process, short-listed candidates will be contacted for a personal interview.
   
5. All applicants will be informed of the final selection decision by early February 2026.

Successful candidates will be requested to inform ICIQ whether they accept or decline the offer within five business days of being notified. If the applicant does not respond during this time, the offer will be considered declined.

ICIQ follows in its selection processes a gender equality opportunity policy and a non-discrimination policy based on age, ethnic or social origin, religion or belief, sexual orientation, language and disability.

VI. Fellowship Conditions

1. The awardees of a ICIQ Severo Ochoa Predoctoral Fellowship for Researchers Training will be considered research personnel in training, and they will have an employment contract (a predoctoral contract), which is regulated in the Spanish Law 14/2011, of June 1^st, of Science, Technology and Education.
   
2. The fellowship conditions are set out in the 2024 ‘Centros de Excelencia «Severo Ochoa» y Unidades «María de Maeztu»’ call for proposals, in the framework of the ‘Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023’. Articles 10, 11 and 29.
   
3. The fellowship includes the salary, the enrolment fees to a PhD program (up to 4 years) and funding to carry out short stays in other institutions, companies or universities abroad.
   
4. Predoctoral contracts are renewed annually for up to 4 years. Renewal is subject to satisfactory performance in the PhD studies and related research activities.
   
5. The gross yearly salary of the contract shall be split into 12 monthly payments and distributed as shown below:
   
   The first year of PhD: 19,574.52 €/year
   The second, third and fourth year of PhD: 24,468.15 € /year
   
   The amounts are stated according to the ‘Estatuto del Personal Investigador en Formación (EPIF)’ rules and Article 10.4 of the 2024 ‘Centros de Excelencia «Severo Ochoa» y Unidades «María de Maeztu»’ call for proposals. They will be increased if the EPIF is updated.

The contract will take effect on the date when the awarded student joins the centre. The fellowship holders can become postdoctoral researchers during a postdoctoral training period (POP) if they defend their PhD thesis before the end of the fellowship. The total duration of both periods (doctoral and postdoctoral) cannot exceed 48 months.

The fellowship includes full social security coverage through the Spanish Social Security system, providing access to the Spanish public health care system and pension and unemployment benefits.

The fellowship holder is entitled to temporarily interrupt the fellowship under the circumstances set forth in Article 21. c) of the Spanish Law 14/2011, of June 1st, of Science, Technology and Education, and in Article 24.5 of the 2024 ‘Centros de Excelencia «Severo Ochoa» y Unidades «María de Maeztu»’ call for proposals (i.e., part-time leave for reasons such as maternity or paternity, reduced working hours due to care of family members). The period of interruption shall not count against the total duration of the fellowship.

The awardees will work full-time at ICIQ and may not receive any other fellowship funding with the same purpose or regular income.

VII. Scientific and technical monitoring of activities for the training of predoctoral researchers.

Predoctoral researchers in training must report to the ‘Agencia Estatal de Investigación’ on the activities carried out and the fulfilment of the training program. They are required to prepare two reports: an interim report at month 20 of the fellowship, and a final report covering the entire duration of the fellowship, including the POP period, if applicable.

Researchers will receive support from the HR Unit and the ICIQ Severo Ochoa Project Manager throughout the entire duration of the fellowship.

VIII. Indicative Calendar

Call opening…………………………………………….……3 November 2025

Call deadline…………………………………………….......11 January 2026

Evaluation and selection process…………….…….January 2026

Final resolution…………..………………………………....From 9 February 2026

Annex: Available positions

Reference: PHD FPI SO 2025-7
Supervisor: Prof. J. R. Galán-Mascarós
Co-supervisor: Prof. Katherine Villa Gómez
Title: Magnetically-Enhanced Photocatalysis for Selective Oxidation of Organic
Molecules
Strategic research line: Renewable Energy Vectors

Reference: PHD FPI SO 2025-8
Supervisor: Prof. Antoni Llobet
Co-supervisor: Prof. Beatriz Prieto-Simón
Title: Nanotechnology for Energy Applications
Strategic research line: Renewable Energy Vectors

Reference: PHD FPI SO 2025-9
Supervisor: Prof. Jordi Burés
Co-supervisor: Prof. Ruben Martin
Title: Unravelling the mechanistic intricacies of catalytic chain-walking reactions
Strategic research line: Innovative Catalysis

Reference: PHD FPI SO 2025-10
Supervisor: Prof. Mónica H. Pérez-Temprano
Co-supervisor: Prof. Jordi Burés
Title: Unveiling C(sp3)–H Activation Principles in Cp*Co(III) Catalysis for Innovative
Synthetic Methodologies
Strategic research line: Innovative Catalysis

Reference: PHD FPI SO 2025-11
Supervisor: Prof. Núria López
Co-supervisor: Prof. Katherine Villa Gómez
Title: Understanding and Predicting Magnetically-Enhanced Photocatalysis for Selective
Oxidation of Organic Molecules
Strategic research line: Renewable Energy Vectors

Reference: PHD FPI SO 2025-12
Supervisor: Prof. Katherine Villa Gómez
Co-supervisor: Prof. Beatriz Prieto-Simón
Title: NIR-Driven Micromotors for Biofilm Eradication and Electrochemical Monitoring
Strategic research line: Molecular Medicine

Reference: PHD FPI SO 2025-13
Supervisor: Arjan W. Kleij
Co-supervisor: Mónica Pérez-Temprano
Title: Light-driven cobalt catalysis
Strategic research line: Innovative Catalysis

Reference: PHD FPI SO 2025-14
Supervisor: José A. Berrocal
Co-supervisor: Pablo Ballester
Title: Mechanoresponsive Polymers with Embedded Macrocycles: Synthesis,
Characterization, and Applications
Strategic research line: Molecular Medicine

Reference: PHD FPI SO 2025-7

Supervisor: Prof. J. R. Galán-Mascarós

Co-supervisor: Prof. Katherine Villa Gómez

Title: Magnetically-Enhanced Photocatalysis for Selective Oxidation of Organic Molecules

Strategic research line: Renewable Energy Vectors

Abstract: The proposed PhD project is aligned with ICIQ’s strategic line on Renewable Energy Vectors, as it explores innovative approaches to convert solar energy into chemical energy through selective oxidation reactions. Specifically, the project will harness visible-light photocatalysis as a sustainable method for activating molecular oxygen and promoting oxidation reactions under mild conditions.

Selective oxidation is a cornerstone of green synthetic chemistry, yet conventional processes rely on harsh oxidants, high temperatures, or precious metals, which limit sustainability. In contrast, photocatalytic oxidation using ambient oxygen offers a route to generate high-value chemicals, such as aldehydes, imines, or acids, directly from alcohols, amines, or biomass-derived substrates, with water as the only by-product.

Importantly, this project introduces a novel and underexplored parameter: external magnetic fields. These fields have the potential to modulate radical reaction pathways, influence spin-selective processes, and improve charge separation efficiency. By investigating the synergy between photocatalysis and magnetic fields, the project proposes a new direction for enhancing selectivity and reactivity in solar-driven oxidation processes.

Tasks to be performed by the PhD student:

• Design, synthesis, and structural/optical characterization of novel photocatalysts (e.g. doped semiconductors, heterojunctions).
• Photocatalytic testing under visible light and evaluation of product selectivity using different organic substrates.
• Implementation of magnetic field systems and systematic evaluation of magnetic effects on photocatalysis: kinetics and selectivity.
• In-depth investigation of reation performance using advanced techniques (e.g. EPR spectroscopy, time-resolved photoluminescence, ROS quantification).
• Interaction with internal and external collaborators, scientific writing, and conference participation.

Preferred skills or background: 

• Materials Science, 
• Chemistry, 
• Nanoscience, 
• Inorganic and analytical chemistry, 
• Magnetism, 
• Solid-state synthesis, 
• Photochemistry, 
• Gas handling.

Supervisor: Prof. Antoni Llobet

Co-supervisor: Prof. Beatriz Prieto-Simón

Title: Nanotechnology for Energy Applications

Strategic research line: Renewable Energy Vectors

Abstract: The main objective of the project is the generation of new hybrid molecular materials for the production of solar fuels. The global shift toward sustainable energy systems demands efficient conversion and storage technologies. This project aims to develop renewable energy vectors derived from CO2 reduction such as Methanol and/or Ethanol (CH₃OH)—through electrocatalytic processes powered by molecular redox catalysts and engineered nanomaterials. The study will explore structure-activity relationships, stability, and potential for scalability. The topic indicated here for the PhD is fully aligned with ICIQ’s strategic line on Renewable Energy Vectors. It explores the hybrid materials-molecules approach to convert solar energy into chemical energy through selective CO2 reduction.

Tasks to be performed by the PhD student:

• Read and review relevant literature;
• Design, fabricate, surface engineer and characterize porous structures, with tunable dimensions, shapes and surface chemistry;
• Asses the electrochemical performance of the developed porous structures;
• Prepare and characterize molecular redox catalysts to be anchored on materials
• Design and apply a range of strategies to chemically functionalize the previous structures to facilitate the incorporation of the synthesized molecular redox catalysts;
• Write reports, publications and thesis;
• Attend group meetings and meetings with collaborators to discuss the progress of the project;
• Attend conferences workshops, etc, to present project results and seek new collaborations.

Preferred skills or background:

• Knowledge and, ideally, some research experience in: materials (synthesis and characterization), molecular chemistry (synthesis of organic ligands and complexes), electrochemistry, surface analysis.
• Demonstrated experience working as part of a team and promoting a collaborative environment.
• The candidate has to be highly motivated and used to work collaboratively.

Supervisor: Prof. Jordi Burés

Co-supervisor: Prof. Ruben Martin

Title: Unravelling the mechanistic intricacies of catalytic chain-walking reactions

Strategic research line: Innovative Catalysis

Abstract: A deep mechanistic understanding of chemical reactions often enables advances that remain out of reach for more empirical, trial-and-error approaches. Focusing on such studies can significantly accelerate the development of catalytic processes, particularly during their early stages, when the accessible chemical space remains vast and largely unexplored. This is precisely the case for catalytic chain-walking reactions, a versatile strategy with broad applicability for repurposing unactivated olefins, abundantly derived from petroleum processing, into high-value chemical entities, offering not only synthetic versatility but also aligning with sustainability efforts by valorizing low-cost feedstocks. These transformations are believed to occur via a formal translocation of the catalyst along the alkyl side chain, enabling the formation of C–C or C–heteroatom bonds “à la carte” at distal, yet previously unfunctionalized, sp³ reaction sites. Despite the advances made, the mechanism by which these reactions operate at the molecular level remains shrouded in mystery, and speculation persists about the factors dictating both reactivity and site-selectivity.

This PhD project aims to tackle this challenge through a combination of experimental techniques and meticulous kinetic studies under the guidance of Prof. Burés, an expert whose pioneering work has demonstrated that deep mechanistic insights yield innovative solutions unattainable by conventional approaches. Given the growing interest in repurposing raw materials through catalytic methods and the untapped potential that Ni catalysis offers for both academic and industrial laboratories, this project is fully aligned with ICIQ’s strategic line on innovative catalysis.

Tasks to be performed by the PhD student:

• Synthesize and characterize relevant organometallic complexes.
• Design and carry out experiments to investigate the mechanism of catalytic chain-walking reactions.
• Employ experimental and analytical techniques to monitor and study reaction processes.
• Analyze data to extract mechanistic and kinetic insights.
• Contribute to the development and optimization of catalytic methodologies.
• Collaborate with internal and external research partners.
• Disseminate research findings through reports, publications, and scientific meetings.

Preferred skills or background:

• MSc in Chemistry or related discipline.
• Strong background in synthetic organic or organometallic chemistry.
• Interest or experience in kinetic studies and reaction mechanism elucidation.
• Familiarity with analytical and spectroscopic techniques (e.g., NMR, IR, HPLC).
• Good level of English and strong communication skills.
• Motivation for interdisciplinary and collaborative research.

Supervisor: Prof. Mónica H. Pérez-Temprano

Co-supervisor: Prof. Jordi Burés

Title: Unveiling C(sp3)–H Activation Principles in Cp*Co(III) Catalysis for Innovative Synthetic Methodologies

Strategic research line: Innovative Catalysis

Abstract: The proposed PhD project aligns with ICIQ’s strategic line on Innovative Catalysis, as it focuses on expanding the catalytic tactics of key field within synthetic organic chemistry: C(sp3)-H functionalization. In particular, this proposal will pursue a mechanism-driven design and development of new methodologies triggered by Cp*CoIII-based systems. This PhD project will implement a synergistic strategy that combines catalytic innovation with in-depth mechanistic studies to unlock new and efficient site-selective C(sp3)–H functionalization reactions. Elucidation of the fundamental principles that control the activation and functionalization of alkylic C–H by Cp*CoIII will enable to create appealing C–C and C–X bond-forming methodologies, including enantioselective protocols. This strategy meets a critical need in the pharmaceutical industry: increasing the three-dimensionality in drug candidates often correlates with enhanced pharmacokinetic properties. By developing Cp*CoIII protocols for site-selective functionalization of unactivated aliphatic C–H bonds, this project will provide new tools for late-stage diversification and the synthesis of more complex three dimensional scaffolds.

Tasks to be performed by the PhD student:

• Development of catalytic processes using first-row transition metals.
• Mechanistic and kinetic studies (including the ability to design complex experiments to gain fundamental insights into the studied reactions).
• Synthesis and characterization of organometallic complexes, organic molecules. and air-sensitive reagents.
• Advanced characterization techniques.
• Application of high-throughput experimentation techniques.
• Writing lab reports and drafting manuscripts for scientific articles.
• Maintenance of the laboratory equipment
• Attending national and international conferences to present the most relevant research results

Preferred skills or background:

We are seeking a motivated candidate with an MSc in synthetic organic and/or organometallic chemistry. Expertise in standard lab techniques and general analytical tools is fundamental. The ideal candidate is expected to be highly motivated, creative, capable of working autonomously, responsible and team player. Excellent communication and management skills, along with reliability in meeting commitments and deadlines are also requested.

Supervisor: Prof. Núria López

Co-supervisor: Prof. Katherine Villa Gómez

Title: Understanding and Predicting Magnetically-Enhanced Photocatalysis for Selective Oxidation of Organic Molecules

Strategic research line: Renewable Energy Vectors

Abstract: The proposed PhD project is aligned with ICIQ’s strategic line on Renewable Energy Vectors, as it explores the modelling of innovative approaches to convert solar energy into chemical energy through selective oxidation reactions. Specifically, the project will require to develop models for visible-light photocatalysis as a sustainable method for activating molecular oxygen and promoting oxidation reactions under mild conditions.

Selective oxidation is a cornerstone of green synthetic chemistry, yet conventional processes rely on harsh oxidants, high temperatures, or precious metals, which limit sustainability. In contrast, photocatalytic oxidation using ambient oxygen offers a route to generate high-value chemicals, such as aldehydes, imines, or acids, directly from alcohols, amines, or biomass-derived substrates, with water as the only by-product. Harnessing the specific chemical potential for the active oxygen species (Reactive Oxygen Species, ROS) is crucial to achieve selectivity in the process.

Introducing the innovation proposed by the groups of Katherine Villa and JR Galán-Mascarós, we will need to adapt the computational simulations of standard reaction processes in photocatalysis to introduce the role of the magnetic fields in the simulations. Different ways to modulate radical reaction pathways, influence spin-selective processes, and improve charge separation efficiency will be explored through these developments. By investigating the synergy between photocatalysis and magnetic fields, the project proposes a new direction for enhancing selectivity and reactivity in solar-driven oxidation processes.

Tasks to be performed by the PhD student:

• Run simulations to incorporate magnetic contributions. Devise models. Prepare and analyze data. Developing needed code.
• Presenting both oral and write reports and drafts on the work done, including the thesis.

Preferred skills or background:

• Physicist, Materials Scientist
• Strong coding abilities (python)
• English

Supervisor: Prof. Katherine Villa Gómez

Co-supervisor: Prof. Beatriz Prieto-Simón

Title: NIR-Driven Micromotors for Biofilm Eradication and Electrochemical Monitoring

Strategic research line: Molecular Medicine

Abstract: Bacterial biofilms represent a major challenge in healthcare and industrial settings due to their resilience to conventional treatments. The development of new tools for their eradication aligns with the Molecular Medicine strategic line, as it directly addresses urgent needs in infection control and biomedical applications. This project proposes the design of NIR-driven micromotors as active antimicrobial agents capable of penetrating and disrupting biofilms under biocompatible irradiation conditions. By integrating electrochemical sensing, we aim not only to allow the early detection of the biofilm to trigger the eradication treatment but also to provide real-time monitoring of the process, which is crucial for translational applications.

Tasks to be performed by the PhD student:

• Conduct a literature review on NIR-driven micromotors, electrochemical sensing, and biofilm removal.
• Fabricate and characterize functional materials, including the development of photoactive micromotors and porous silicon structures with tunable morphology and surface chemistry.
• Study bacterial biofilm formation, grow and characterize biofilms on porous silicon using microscopy and staining techniques, evaluate the antibiofilm activity of micromotors.
• Perform electrochemical analyses, assess biofilm-related physicochemical changes and monitor biofilm eradication in real time via electrochemical readouts.
• Prepare scientific reports, publications, and the PhD thesis.

Preferred skills or background:

• MSc in Materials Science, Chemistry, Nanotechnology, or related fields.
• Experience or strong interest in materials synthesis and characterization, microbiology (bacterial culture), photocatalysis, electrochemistry, and surface analysis.

Supervisor: Arjan W. Kleij

Co-supervisor: Mónica Pérez-Temprano

Title: Light-driven cobalt catalysis

Strategic research line: Innovative Catalysis

Abstract: The proposed PhD project aligns with ICIQ’s strategic line on Innovative Catalysis, as it focuses on expanding the catalytic tactics at the intersection of first-row transition metal catalysis, photochemistry and enantioselective synthesis. In particular, this PhD project will pursue a mechanism-driven design and development of light-driven CpXCoI-systems to achieve selective cleavage of C(sp3)–heteroatom bonds and unlock novel cobalt-catalyzed cross-coupling manifolds, including enantioselective protocols.

This strategy aligns sustainability goals while meeting a pressing pharmaceutical need: efficient late-stage diversification to generate 3D and stereo-defined scaffolds correlated with improved pharmacokinetic properties. Overall, the program couples catalytic innovation with deep mechanistic insights to deliver broadly useful methodologies aligned with ICIQ’s mission to be a leading institute on medicinal discovery.

Tasks to be performed by the PhD student:

Synthesis of Co-complexes and their analysis by spectroscopic and structural studies, their use in photo-catalytic organic chemistry based transformations and investigating the mechanistic features by experimental (NMR, EPR, X-ray, MS, Stern-Volmer) and computational techniques (DFT; in collaboration).

Preferred skills or background:

The candidate has ideally a background in organometallic chemistry and/or (photo)catalysis, with appreciation of mechanistic understanding and analysis. Organic chemistry experience is highly appreciated. A good level of English, a pro-active, independent attitude towards problem-solving and experience with writing scientific reports is also appreciated.

Supervisor: José A. Berrocal

Co-supervisor: Pablo Ballester

Title: Mechanoresponsive Polymers with Embedded Macrocycles: Synthesis, Characterization, and Applications

Strategic research line: Molecular Medicine/Innovative Catalysis

Abstract: This PhD project explores the use of molecular receptors embedded in rationally designed force-responsive polymers as a platform to modulate molecular recognition and chemical reactivity within confined spaces. This concept aligns with two of the three strategic research lines of the Severo Ochoa Action Plan:

In the area of Molecular Medicine, the integration of host–guest chemistry into force-responsive polymers represents a novel strategy for developing mechanically regulated molecular recognition and sensing platforms. These approaches hold strong potential for the development of smart materials for biomedical applications.

In the context of Innovative Catalysis, the project aims to develop bio-inspired catalysts that mimic the confined and adaptive nature of enzyme active sites. By embedding macrocyclic receptors with well-defined cavities into functional polymeric matrices, we will investigate how mechanical forces can modulate both the reactivity and selectivity in these confined environments. This strategy opens new avenues for developing stimuli-responsive catalytic systems with controllable activity

Tasks to be performed by the PhD student

• Synthesis and characterization of macrocycles and small molecules/monomers.
• Evaluation of macrocycle’s binding affinity in solution for model guests.
• Incorporation of the latter in polymer materials via different polymerization techniques (UV curing, RAFT, ATRP, click chemistry, …).
• Characterization of the thermal and mechanical properties of the realized polymer materials (techniques: DSC, TGA, DMA, rheology, tensile properties, …).
• Investigation of the responsive behavior of these polymers under mechanical deformation (with an in-house built setup that combines instruments providing optical and mechanical properties).
• Update the group/supervisor on the latest results in the form of presentations and written reports.
• Active participation in discussion meetings and brainstorming sessions.

Preferred skills or background

• Masters degree in Chemistry or Polymer Chemistry
• Previous experience in the synthesis of macromolecules or small organic molecules, and/or background in photoswitches, supramolecular chemistry, or physical organic chemistry.
• Ability to work independently but also serve as a team member.
• Good communication skills
• Good level of spoken and written English, at least an intermediate level of English (B1 or higher).
• Willingness to undergo a robust training in soft skills (e.g., scientific writing and communication) and mentoring (e.g., organization skills and career planning), which the supervisor commits to provide.
• Reliable in meeting commitments and deadlines.
• Strong commitment for scientific research.

The Institute of Chemical Research of Catalonia (ICIQ), in the framework of the ICIQ Severo Ochoa Excellence Program 2025-2029, establishes the ICIQ Severo Ochoa International Mobility Program with the aim to support excellent early-stage researchers to carry out a short-term research stay from three to four months in an international institution abroad. These grants aim to allow young ICIQ researchers to experience a different research environment and complement their research training.

ICIQ offers up to 10 ICIQ Severo Ochoa International Mobility (SOIM) Grants for PhD students in their 3rd or 4th year of doctoral studies. Candidates may freely propose a research project to be carried out at an international host institution of their choice. Only R&D institutions different from those in which candidates completed their graduate studies are eligible.

The application must clearly state why the applicant has chosen the specific research institution and how the stay creates research synergies between the ICIQ and the host institution. In any case, it will be essential to have written approval from the ICIQ supervisor(s) to proceed with the planned stay.

The process of evaluation and selection guarantees the principles of competition, publicity and transparency.

I. Eligibility criteria

The program is open to ICIQ researchers that fulfil the following eligibility criteria at the time of the deadline (25 July 2025):

a. PhD students in their third or four year of predoctoral contract. Only students who have a predoctoral labour contract exclusively with ICIQ are eligible for these grants.

b. The predoctoral contract must be in force throughout the entire duration of the research stay.

c. The host institution must be different from the University/R&D Centre where the candidates completed their graduate studies.

d. The successful candidates should have a convincing and well-planned research proposal for the short-term stay that has been agreed with an academic supervisor at the prospective host institution. A declaration of interest letter from the supervisor at the host institution will be asked to the fellows before the start date of the grant.

e. Applicants should state whether applications have been submitted to other funding bodies for the same purpose and whether any other grants have been received towards the same visit.

Candidates who fulfil the eligibility criteria will be evaluated according to the Evaluation Criteria described in section V.

II. Incompatibilities

1. At the time of submitting the application, candidates cannot have benefited from any other grant for short-term stays during their predoctoral training.

2. SOIM Grants may not be used to complement, or as an extension to, another short-term grant.

3. Candidates cannot benefit at the same time from a Marie Skłodowska-Curie Action, FPI Fellowship or FPU Fellowship (Predoctoral Fellowships funded by the MICIU/AEI), or INPhINIT Fellowship (“la Caixa” Foundation).

When in doubt regarding the eligibility criteria or possible incompatibilities, applicants should contact ICIQ’s Severo Ochoa project manager at ssayalero@iciq.es before submission of the application.

III. Benefits of the Grant

1. From three to four months of secondment support. The length of the grant will depend on the proposed research project and the candidate's work plan.
2. Monthly allowance that will be calculated according to the regulations set out for short-term research stays in the 2024 ‘Centros de Excelencia «Severo Ochoa» y Unidades «María de Maeztu»’ call for proposals, in the framework of the ‘Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023’ of the Ministerio de Ciencia, Innovación y Universidades / Agencia Estatal de Investigación (MCIU/AEI). Articles 9.3.e) and 10.5.a).
3. A round-trip airfare from ICIQ to the host institution and travel expenses, in accordance with ICIQ and MICIU/AEI regulations.
4. Visa fees and accident insurance and health insurance, when the stay is in countries where the European Health Card is not valid nor the Provisional Substitute Certificate for the European Health Card.

IV. Application process

The application period opens on June 16 and closes at midnight (Spain time) on July 25, 2025.

Only one application per person will be considered. In case of multiple applications, only the first application submitted will be taken into consideration. Candidates must ensure that all information is included before the deadline. There will not be the possibility to modify the application or to add missing documentation after the call deadline.

The entire application process will be completed online. Applicants must apply via ICIQ’s Career Portal. Applications sent by email or any other means will be ineligible.

After completing the online form, applicants must attach the following documents:

1. A motivation letter that must clearly state why the applicant has chosen the host research institution and how the short-term stay will impact the candidate’s professional career and create research synergies between the ICIQ and the host institution.
2. Curriculum Vitae (4 pages maximum). The CV must include education and career information, list of publications and patents, information on previous research stays and mention of the most relevant achievements sorted by the typology that best suits the candidate’s scientific profile (fellowships and awards, participation in scientific conferences and congresses, participation in R&D projects, training activities, outreach activities, etc.).
3. Description of the planned research work which has been agreed upon with the supervisor at the host institution. The research proposal must follow the template available on the application portal.

Once the application has been successfully completed, an acknowledgement e-mail will be automatically sent. Candidates must ensure that all information is included before the deadline. Incomplete applications will not be considered.

V. Evaluation and Selection Process

The evaluation and selection of the candidates will be conducted by the Severo Ochoa Committee for Predoctoral Training following the guidelines set by the 2024 ‘Centros de Excelencia «Severo Ochoa» y Unidades «María de Maeztu»’ call for proposals, supported by the Human Resources team, and following the procedure below:

1. All the applications will be checked for eligibility and those not fulfilling all the criteria will be rejected. Incomplete and/or ineligible applications will be also discarded at this stage.
2. The evaluation and selection process carried out under this call will observe the principles of the San Francisco Declaration on Research Assessment (DORA), signed in San Francisco, California, on December 16, 2012 (https://sfdora.org/read).
3. Admission to the program is on a competitive basis. All applications will be evaluated on the basis of the candidate’s excellence, the stage of development of PhD Thesis and the quality of the research proposal.
4. The name of the awardees will be published on the ICIQ’s website.
5. All applicants will be informed of the final selection decision by early September 2025.

In the event that an awardee obtains a short-term fellowship through another competitive call for applications, this must be communicated to the Severo Ochoa project manager (ssayalero@iciq.es) as soon as possible. The SOIM Fellowship will then be allocated to the candidate at the top of the reserve list.

ICIQ follows in its selection processes a gender equality opportunity policy and a non-discrimination policy based on age, ethnic or social origin, religion or belief, sexual orientation, language and disability.